Does a dose-response relationship reduce sensitivity to hidden bias?

Does a dose-response relationship reduce sensitivity to hidden bias?

It is often said that an important consideration in judging whether an association between treatment and response is causal is the presence or absence of a dose-response relationship, that is, larger ostensible treatment effects when doses of treatment are larger. This criterion is widely discussed in textbooks and is often mentioned in empirical papers. At the same time, it is well known throu...

Mutagen Sensitivity Exhibits a Dose-Response Relationship in Case-Control

We have been quantitating, as a marker of cancer susceptibility, induced chromatid breaks in lymphocyte cultures exposed to chemical mutagens. This report highlights the consistency of the results from two casecontrol studies, using different methods of presenting the data. In both the lung cancer case-control study, which used bleomycin, a radiomimetic agent, as the test mutagen, and the melan...

Detection Sensitivity and Response Bias

Does Registration Reduce Publication Bias? A Holiday Puzzle

Albert Fang, Grant Gordon, and Macartan Humphreys Department of Political Science, Columbia University December 31, 2014 1 The Problem There is a lot of worry about publication and analysis bias in social science research. It seems results are much more likely to be published if they are statistically significant than if not which can lead to very misleading inferences (Gerber and Malhotra, 200...

Sensitivity to vecuronium in myasthenia gravis: a dose-response study.

A cumulative dose plus infusion technique and integrated EMG monitoring of the first dorsal interosseous muscle were used to determine the potency of vecuronium in 20 normal patients and in ten patients with myasthenia gravis under thiamylal, N2O, O2, fentanyl anaesthesia. The mean (+/- SEM) values for ED50, ED90, and ED95 in the normal patients were 19 +/- 1, 31 +/- 1 and 36 +/- 2 micrograms.k...